Response to Antigen: Processing and Presentation MHC Restriction and Role of the Thymus
تاريخ النشر : 2015-04-08 22:48:05
عدد المشاهدات : 172
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1)Originally identified in mice as blood cell antigens by R.A. Gorer and G.D. Snell in 1930s, and defined on the basis of tissue graft rejection - 1980 Nobel prize awarded to Snell.
2)Work by Rolf Zinkernagel and Peter Doherty in the 1970s revealed that it is the complex of MHC molecule plus antigen that is recognized by T cells (MHC restriction of T cell responses) - 1996 Nobel Prize
3)Two classes of MHC molecule: Class I (single MHC a chain + b2-microglobulin) and Class II (a chain plus b chain) - more Ig-superfamily members (Ig-C domains)